… the CC/DB domain interface or the ND dimer interface block … that STAT-1 increases the levels
of both IL-12 and TNF-α in … this differentiation, IL-12 binds to the IL-12 receptor (IL-12R) and …

… [24] PEG conjugated to IFN-α at IFN/IFNR-binding interface … IL-12 binds to the IL-12 receptor
(IL-12R), which is expressed … T cell lymphoma, acquired immunodeficiency syndrome (AIDS)…

… expression of IL-12R and Interferon gamma receptor 1 (IFN-… evolution of a child with complete
IL-12 Rβ1 deficiency. CNS TB is … or any other cause of immunodeficiency such as MSMD. …

… of IL-12 and IFN-β by DC. At the early stage of infection, … receptor (IL-12R) complex, which
is composed of two chains: IL-… either of the two IFN-γR chains or STAT-1 is associated with the …

… vigorous [4], as the described deficiencies in IL-12, IFN-γ or TNF pathways that lead to the
… In fact, defects in the IL-12-IFN-γ axis led to immune deficiency and intersect with the IFN-γ-…

… factors (STAT-1, STAT-4, T-bet) and is also favored by the release of co-stimulatory signals
(together with IL-12) such as CD40 and CD80 by APC cells: IL-12 will bind to IL-12R (receptor…

… of the innate immune system, interferons provide an early … -JAK-STAT signaling can result
in immunodeficiency (25, 26). If the … IL-12 and IL-23 signaling sustains chronic inflammation by …

… IFN-γ has been shown … , IL-12 and IL-23 are generally responsible for inducing RA.
Development of ustekinumab (Stelara), a humanized mAb that binds the shared p40 subunit of IL-12 …

… Activation of innate immune cells through PRRs also triggers … such as type I interferons
(IFNα/β), IL-12 and IFN-γ95. Antigen … interfaces between the surfaces of interacting immune cells, …

… illness in patients with IL-12 deficiency or IL-12R deficiency. … of STAT-1 GOF, APDS1 and
APDS2 patients. Citation132 … programs for primary immunodeficiency diseases enable early …